2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107608
    Leukotriene B4 71160-24-2 ≥98.0%
    Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Leukotriene B4
  • HY-126885
    DBCO-PEG5-NHS ester 2144395-59-3
    DBCO-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG5-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG5-NHS ester
  • HY-22340
    Azido-PEG4-alcohol 86770-67-4 98.88%
    Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG4-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-alcohol
  • HY-W008474
    Boc-NH-PEG2-C2-NH2 153086-78-3 99.38%
    Boc-NH-PEG2-C2-NH2 (PROTAC Linker 13) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Boc-NH-PEG2-C2-NH2
  • HY-W123015
    6-Azidohexanoic acid 79598-53-1 99.20%
    6-Azidohexanoic acid is an ester product.
    6-Azidohexanoic acid
  • HY-140895
    Biotin-PEG4-amine 663171-32-2 98.0%
    Biotin-PEG4-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-amine
  • HY-140755
    Aeide-C1-NHS ester 824426-32-6 98.0%
    Aeide-C1-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Aeide-C1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Aeide-C1-NHS ester
  • HY-130485
    Bromo-PEG2-C2-azide 530151-56-5 98.70%
    Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG2-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Bromo-PEG2-C2-azide
  • HY-140941
    Biotin-PEG2-C2-iodoacetamide 292843-75-5 98.23%
    Biotin-PEG2-C2-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG2-C2-iodoacetamide
  • HY-138461
    Azido-PEG1 1517-05-1 99.98%
    Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1
  • HY-W007713
    Fmoc-8-amino-3,6-dioxaoctanoic acid 166108-71-0 99.98%
    Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-8-amino-3,6-dioxaoctanoic acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-8-amino-3,6-dioxaoctanoic acid
  • HY-140921
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide 1260247-50-4 98.0%
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG4-amino-t-Bu-DADPS-C6-azide
  • HY-140274
    DBCO-PEG12-NHS ester 2093934-94-0 98.68%
    DBCO-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-NHS ester
  • HY-140736
    DSPE-PEG2000-Biotin 385437-57-0 99.93%
    DSPE-PEG2000-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG2000-Biotin
  • HY-141269
    Methyltetrazine-PEG5-NHS ester 1802907-92-1
    Methyltetrazine-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG5-NHS ester
  • HY-130184
    Azido-PEG8-NHS ester 1204834-00-3 99.47%
    Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG8-NHS ester
  • HY-140764
    Azido-PEG3-NHS ester 1092654-47-1 ≥98.0%
    Azido-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-NHS ester
  • HY-130653
    Azido-PEG4-C2-acid 1257063-35-6 99.20%
    Azido-PEG4-C2-acid a PEG-based PROTAC linker can be used in the synthesis of vRucaparib-TP4. Azido-PEG4-C2-acid is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-C2-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG4-C2-acid
  • HY-W008352
    Boc-NH-PEG4-CH2CH2NH2 811442-84-9 ≥98.0%
    Boc-NH-PEG4-CH2CH2NH2 a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-NH-PEG4-CH2CH2NH2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG4-CH2CH2NH2
  • HY-W007803
    Boc-NH-C4-Br 164365-88-2 98.0%
    Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-C4-Br
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.